Investigating how autoantibodies affect coordination and movement in the brain.
Pathological Mechanisms of Immune-Mediated Cerebellar Ataxia with Associated Sez6L2 Autoantibodies
This study is looking into how certain antibodies might be linked to cerebellar ataxia, a condition that makes it hard to coordinate movements and maintain balance, using mice to see if these antibodies cause damage or just indicate other immune issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10526475 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Sez6L2 autoantibodies in causing cerebellar ataxia, a condition that affects coordination and balance. By using mouse models, the researchers will explore whether these autoantibodies directly damage the cerebellum or if they serve as markers for underlying autoimmune processes. The study will involve various methodologies, including behavioral assessments and analysis of immune cell populations, to uncover the mechanisms behind the symptoms experienced by affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing symptoms of cerebellar ataxia, such as gait disturbances, slurred speech, and cognitive deficits, potentially linked to autoantibodies.
Not a fit: Patients with cerebellar ataxia not associated with autoimmune mechanisms or those without detectable Sez6L2 autoantibodies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment and management of cerebellar ataxia caused by autoimmune responses.
How similar studies have performed: While the specific focus on Sez6L2 autoantibodies is novel, similar studies investigating autoimmune mechanisms in cerebellar ataxia have shown promising results.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Hammond, Jennetta W — University of Rochester
- Study coordinator: Hammond, Jennetta W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.