Investigating how autism risk genes affect cognitive aging in autistic adults
Official title: The Role of Autism Risk Genes in Cognitive and Brain Aging Outcomes of Autistic Adults
Funded at Arizona State University-Tempe Campus · NIH-10997692 · Data updated 2026-11-12
This study is looking at how certain genes linked to autism might affect memory and brain aging in autistic adults over 21, and it wants to see if there are differences between men and women in this process.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31MH138112-01 |
| Project ID | NIH-10997692 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are autistic adults aged 21 and older, particularly those concerned about cognitive aging or Alzheimer's disease risk.
✕Less likely to help
Patients who are not autistic or those under the age of 21 may not benefit from this research.
What this research studies
This research explores the connection between autism risk genes and cognitive aging outcomes in autistic adults, particularly those aged 21 and older. It aims to understand how these genetic factors may contribute to accelerated memory decline and brain aging compared to neurotypical individuals. By utilizing polygenic risk scores, the study will assess the impact of multiple genetic variations on cognitive functions and brain structure. The research will also examine potential sex differences in these aging processes among autistic adults.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and interventions for cognitive decline in autistic adults as they age.
How similar studies have gone: While there is limited research specifically addressing this topic, the approach of using polygenic risk scores has shown promise in other genetic studies related to aging and cognitive decline.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Harker, Samantha — Arizona State University-Tempe Campus
- Study coordinator: Harker, Samantha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.