Investigating how Ataxin-2 affects TDP-43 transport and RNA regulation in neurons
Role of Ataxin-2 polyglutamine expansion on TDP-43 transport and post-transcriptional RNA regulation in neurons
This study is looking at how two proteins, Ataxin-2 and TDP-43, work together in the brain and how this affects nerve cell function, which could help us find new ways to treat conditions like ALS and frontotemporal dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10863865 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between Ataxin-2 and TDP-43, two proteins involved in neurodegenerative diseases like ALS and frontotemporal dementia. By studying these interactions, the research aims to uncover how they influence RNA regulation, which is crucial for neuron function. The approach includes examining cellular mechanisms and molecular pathways that may contribute to the progression of these diseases. Patients may benefit from insights that could lead to new therapeutic strategies targeting RNA metabolism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ALS or frontotemporal dementia, particularly those with genetic mutations related to TDP-43 or Ataxin-2.
Not a fit: Patients with neurodegenerative diseases not related to ALS or frontotemporal dementia may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the quality of life and extend survival for patients with ALS and frontotemporal dementia.
How similar studies have performed: Previous research has shown promising results in understanding the role of RNA-binding proteins in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Gopal, Pallavi P. — Yale University
- Study coordinator: Gopal, Pallavi P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.