Investigating how astrocytes influence the risk of developing cerebral adrenoleukodystrophy.
Official title: Use of IPSC to define role of astrocytes in specifying risk for onset of cerebral adrenoleukodystrophy
Funded at Henry Ford Health System · NIH-10879158 · Data updated 2026-11-12
This study is looking at how a specific type of brain cell called astrocytes behaves in people with X-linked adrenoleukodystrophy (X-ALD) to find clues that could help improve treatment and management of the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health System NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $343,065 |
| NIH project number | 5R01NS114245-04 |
| Project ID | NIH-10879158 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are male patients diagnosed with X-linked adrenoleukodystrophy, particularly those exhibiting either the cerebral or adrenomyeloneuropathy phenotypes.
✕Less likely to help
Patients with other forms of adrenoleukodystrophy or those without a diagnosis of X-ALD may not benefit from this research.
What this research studies
This research aims to understand the role of astrocytes, a type of brain cell, in the progression of X-linked adrenoleukodystrophy (X-ALD) from benign to severe forms. By using induced pluripotent stem cells (iPSCs) derived from patients, researchers will study the metabolic differences in astrocytes from individuals with different X-ALD phenotypes. The goal is to identify potential biomarkers and therapeutic targets that could help predict and treat this condition more effectively. Patients may benefit from insights that could lead to better management strategies for X-ALD.
Why it matters
Potential benefit: If successful, this research could lead to improved prognostic indicators and new treatment options for patients with X-ALD.
How similar studies have gone: While the specific approach using iPSCs to study astrocytes in X-ALD is relatively novel, similar methodologies have shown promise in other neurological conditions.
Where this research is happening
-
Henry Ford Health System
Detroit, United States Active
Researchers
- Principal investigator: Singh, Jaspreet — Henry Ford Health System
- Study coordinator: Singh, Jaspreet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.