Investigating how astrocytes in the optic nerve head respond in glaucoma
Modulation of optic nerve head astrocyte reactivity in glaucoma
This study is looking at how certain supportive cells in the eye, called astrocytes, respond to high pressure in the eye, which can lead to glaucoma, and it hopes to find new ways to protect vision for people at risk of this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10894821 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of astrocytes, a type of supportive cell in the optic nerve head, in the development of glaucoma, a leading cause of blindness. By studying how these cells react to elevated intraocular pressure, the research aims to uncover early cellular changes that could lead to axon injury. The approach involves using rodent models to observe the behavior of astrocytes and their cytoskeletal changes, which may provide insights into potential new treatments for glaucoma. The ultimate goal is to identify novel therapeutic strategies that can protect vision by targeting the optic nerve head.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for glaucoma or those diagnosed with the condition.
Not a fit: Patients with glaucoma who are already at an advanced stage of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent vision loss in glaucoma patients.
How similar studies have performed: Previous research has shown promise in targeting astrocyte reactivity in neurodegenerative diseases, suggesting that this approach may yield beneficial results.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Morrison, John C — Oregon Health & Science University
- Study coordinator: Morrison, John C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.