Investigating how astrocytes develop in the human brain
Understanding glial fate restriction in humans
['FUNDING_R01'] · HARVARD UNIVERSITY · NIH-11132906
This study is looking at how a special type of brain cell called astrocytes is formed during human brain development, which could help us understand brain function better and improve our knowledge of diseases related to these cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD UNIVERSITY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11132906 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanisms that lead to the formation of astrocytes, a crucial type of brain cell, during human brain development. By examining the spatio-temporal patterns of astrocyte production, the study aims to uncover how these cells are generated from progenitor cells in the cortex. The research will utilize advanced methodologies to analyze human brain tissue, addressing the challenges posed by ethical considerations and differences between human and animal models. Insights gained from this research could enhance our understanding of brain function and the development of astrocyte-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include adults with neurological disorders or conditions that affect astrocyte function.
Not a fit: Patients with conditions unrelated to astrocyte function or those outside the adult age range may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for diseases related to astrocytes, improving outcomes for patients with neurological conditions.
How similar studies have performed: Other research has shown success in understanding astrocyte development in animal models, but this approach is novel in the context of human brain development.
Where this research is happening
CAMBRIDGE, UNITED STATES
- HARVARD UNIVERSITY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAMANATHAN, SHARAD — HARVARD UNIVERSITY
- Study coordinator: RAMANATHAN, SHARAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.