Investigating how astrocytes contribute to Alzheimer's disease through specific signaling pathways
Official title: Astrocytic OSMR/JAK/STAT signaling in AD
Funded at Augusta University · NIH-11010856 · Data updated 2026-11-12
This study is exploring how certain brain cells called astrocytes change when there’s inflammation in Alzheimer’s disease, and how these changes might affect memory and thinking skills, using both animal models and human brain samples to find out more.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $626,766 |
| NIH project number | 5R01AG075057-03 |
| Project ID | NIH-11010856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it due to age or genetic factors.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of reactive astrocytes in the development of Alzheimer's disease (AD). It examines how these cells change their functions in response to inflammatory signals and how this affects the progression of AD. The study specifically looks at the JAK/STAT signaling pathway, which is activated in astrocytes during AD, and how this activation influences other brain cells and contributes to cognitive decline. By using animal models and analyzing human brain samples, the research aims to uncover the mechanisms behind astrocyte reactivity in AD.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting astrocyte signaling pathways to slow or prevent the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in targeting astrocyte signaling pathways in other neurodegenerative diseases, suggesting potential for success in this area as well.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Wang, Qin — Augusta University
- Study coordinator: Wang, Qin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.