Investigating how astrocytes affect the progression of ALS.
Modulating an Astrocyte Hemichannel to Delay Spatial and Temporal Progression in ALS.
This study is looking at how a special type of brain cell called astrocytes affects the progression of ALS, with the hope of finding new ways to slow down the disease and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10866604 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of astrocytes, a type of brain cell, in the progression of Amyotrophic Lateral Sclerosis (ALS). By examining how these cells communicate and function in the central nervous system, the study aims to identify potential therapeutic targets that could slow down disease progression. The approach includes analyzing astrocyte behavior in both human samples and animal models to uncover mechanisms that contribute to ALS. Patients may benefit from insights that could lead to new treatment strategies aimed at modifying the course of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Amyotrophic Lateral Sclerosis.
Not a fit: Patients with other neurological conditions unrelated to ALS may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly slow the progression of ALS.
How similar studies have performed: Previous studies have shown promising results in understanding astrocyte function in ALS, suggesting that this approach could lead to meaningful advancements in treatment.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Maragakis, Nicholas J — Johns Hopkins University
- Study coordinator: Maragakis, Nicholas J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.