Investigating how asporin affects heart remodeling and cell survival
Asporin, an extracellular protein, regulates cardiac remodeling
This study is looking at a protein called asporin to see how it affects heart cells during stress or injury, with the goal of finding new ways to help people with heart failure feel better and keep their heart cells healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10862644 on NIH RePORTER |
What this research studies
This research explores the role of asporin, a protein found in the extracellular matrix, in the process of cardiac remodeling, which occurs during heart stress or injury. The study aims to understand how asporin influences TGFβ signaling and cell viability in heart cells, particularly fibroblasts and cardiomyocytes. By examining these mechanisms, the research seeks to identify potential therapeutic strategies that could enhance heart function and prevent cell death in patients with heart failure. The approach includes testing how asporin can be delivered effectively to target heart cells and improve their survival during adverse conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing cardiac remodeling or heart failure.
Not a fit: Patients with stable heart conditions or those not experiencing cardiac stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and reduce the risk of heart failure.
How similar studies have performed: Previous research has shown promising results in using similar approaches to target cardiac remodeling, indicating potential for success in this area.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Parker, Sarah J — Cedars-Sinai Medical Center
- Study coordinator: Parker, Sarah J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.