Investigating how AS160 regulates heart response to metabolic stress
AS160 as a nodal regulator of the cardiac response to metabolic stress
This study is looking at how a protein called AS160 affects heart health in people with obesity and diabetes, to find ways to improve heart function and overall health for those dealing with metabolic issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10894075 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of AS160 in the heart's response to metabolic stress, particularly in individuals with obesity and diabetes. The study aims to explore how cardiac metabolism affects overall metabolic health and how dysfunction in heart cells can lead to systemic metabolic issues. By examining the interactions between cardiac function and metabolic pathways, the research seeks to identify potential therapeutic targets for improving heart health in patients with metabolic syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing obesity, diabetes, or related metabolic disorders.
Not a fit: Patients without metabolic syndrome or those who are not affected by obesity or diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health and metabolic function in patients with obesity and diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between cardiac function and metabolic health, suggesting that this approach could yield significant insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Schumacher, Sarah Marie — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Schumacher, Sarah Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.