Investigating how artemin/GFRα3 signaling contributes to pain in osteoarthritis
Evaluation of mechanistic role of artemin/GFRα3 signaling in osteoarthritis pain
This study is looking at how a specific pathway in the body, involving a substance called artemin and its receptor, affects pain in people with osteoarthritis, with the goal of finding better ways to help manage that pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-10821315 on NIH RePORTER |
What this research studies
This research explores the role of a specific signaling pathway involving artemin and its receptor GFRα3 in the pain experienced by individuals with osteoarthritis (OA). The study aims to identify how this pathway contributes to the initiation and maintenance of OA pain, which affects millions of adults. By understanding this mechanism, researchers hope to develop new therapeutic targets that could lead to more effective pain management strategies for OA patients. The approach includes examining the effects of this signaling pathway in various species, including humans, to validate its relevance.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who suffer from osteoarthritis and experience chronic pain.
Not a fit: Patients with osteoarthritis who do not experience significant pain or those with other forms of arthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce pain and improve the quality of life for patients with osteoarthritis.
How similar studies have performed: While the specific pathway being investigated is novel, similar research has shown promise in identifying new pain management strategies for chronic pain conditions.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Mishra, Santosh K. — North Carolina State University Raleigh
- Study coordinator: Mishra, Santosh K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.