Investigating how arsenic exposure affects lipid accumulation in the intestines
APOB48 downregulation is the causing factor in mediating iAs-induced lipid accumulation in enterocytes
This study is looking at how being exposed to arsenic early in life affects fat buildup in the intestines, using baby mice to see how it might impact their digestive health and overall well-being.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10538854 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of early life exposure to arsenic on lipid accumulation in the intestines. By administering inorganic arsenic to neonatal mice, the study examines how this exposure leads to oxidative stress and alters gene expression in intestinal tissues. The researchers aim to uncover the mechanisms behind lipid accumulation in enterocytes, which could have significant implications for digestive health and overall well-being. The findings may help identify potential health challenges arising from arsenic exposure during critical developmental stages.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to arsenic, especially during early life, and may be experiencing related health issues.
Not a fit: Patients who have not been exposed to arsenic or do not have conditions related to lipid metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of health issues related to arsenic exposure, particularly in vulnerable populations.
How similar studies have performed: While the specific focus on arsenic's effects on lipid accumulation in the intestines is novel, there is existing research on arsenic exposure and its health impacts, indicating potential for significant findings.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Tukey, Robert H — University of California, San Diego
- Study coordinator: Tukey, Robert H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.