Investigating how arsenic and nickel cause cancer in human lung cells
Arsenic and Nickel Carcinogenesis in Human Lung Cells
This study is looking at how a gene called SATB2 might play a part in lung cancer caused by exposure to metals like arsenic and nickel, and it aims to find out how these metals affect this gene to help us understand how to better prevent or treat these types of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10681242 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific gene, SATB2, in the development of cancer caused by exposure to arsenic and nickel in human lung cells. The study examines how the expression of SATB2 is influenced by these metals and how its regulation can lead to cancerous transformations in cells. By using various techniques, including gene knockdown and chemical inhibitors, researchers aim to uncover the mechanisms that allow these carcinogens to promote cancer cell growth and invasion. The findings could provide insights into potential therapeutic targets for preventing or treating metal-induced cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have been exposed to arsenic or nickel and are at risk for lung cancer.
Not a fit: Patients who have not been exposed to arsenic or nickel or who do not have lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lung cancers associated with arsenic and nickel exposure.
How similar studies have performed: Other research has shown success in understanding the mechanisms of carcinogenesis related to metal exposure, making this approach both relevant and promising.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Costa, Max — New York University School of Medicine
- Study coordinator: Costa, Max
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.