Investigating how ApoE4 affects Alzheimer's disease risk and resistance
Study Susceptibility and Resistance to ApoE4 in Alzheimer's Disease
['FUNDING_OTHER'] · J. DAVID GLADSTONE INSTITUTES · NIH-10418144
This study is looking at how a specific gene called ApoE4 affects the risk of developing Alzheimer's disease and why some people with this gene don’t show symptoms, using aged mice to find clues that could help create better treatments for Alzheimer's in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | J. DAVID GLADSTONE INSTITUTES (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10418144 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the ApoE4 gene in Alzheimer's disease (AD), particularly how it influences the risk of developing the condition and why some individuals with this gene remain asymptomatic. The study involves examining the brain activity of aged mice with the ApoE4 gene to identify mechanisms that contribute to memory impairments associated with AD. By exploring these mechanisms, the research aims to uncover new therapeutic targets that could lead to better treatments or preventive strategies for Alzheimer's disease. Patients may benefit from insights gained that could inform future therapies tailored to their genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a genetic predisposition to Alzheimer's disease, particularly those carrying the ApoE4 allele.
Not a fit: Patients without any genetic risk factors for Alzheimer's disease or those already diagnosed with advanced stages of the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat Alzheimer's disease, particularly for those at high genetic risk.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in Alzheimer's disease, but this specific approach focusing on ApoE4 mechanisms is relatively novel.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- J. DAVID GLADSTONE INSTITUTES — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, YADONG — J. DAVID GLADSTONE INSTITUTES
- Study coordinator: HUANG, YADONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia, Alzheimers disease