Investigating how ApoE and ABCA1 affect brain cell function in Alzheimer's disease
ApoE, ABCA1 and endosomal dysregulation in AD
This study is looking at how a specific protein related to aging affects the way brain cells work, with the goal of finding new ways to help keep our brains healthy and lower the chances of developing Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10796884 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the ApoE4 protein and ABCA1 in the regulation of endosomal trafficking, which is crucial for brain cell function. It examines how aging and the presence of the APOE4 allele influence these processes in brain cells, including astrocytes and neurons. By studying these mechanisms, the research aims to uncover potential therapeutic targets that could improve brain health and reduce the risk of Alzheimer's disease. The approach involves both laboratory experiments and analysis of genetic factors in animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are carriers of the APOE4 allele and are at risk for developing Alzheimer's disease.
Not a fit: Patients who do not carry the APOE4 allele or who have already been diagnosed with advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the mechanisms of ApoE and ABCA1.
How similar studies have performed: Previous research has shown promising results in understanding the role of ApoE in Alzheimer's disease, indicating that this approach has the potential for significant insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Yassine, Hussein N — University of Southern California
- Study coordinator: Yassine, Hussein N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.