Investigating how APOE ε4 affects communication between brain cells in Alzheimer's disease
APOE e4 negative regulation of microglia-astrocytes crosstalk in Alzheimer's disease
This study is looking at how certain brain cells work together in Alzheimer's disease, especially in people with a gene that raises their risk, to find new ways to help manage the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10429190 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of microglia, a type of brain cell, in Alzheimer's disease and how they interact with astrocytes, another type of brain cell. The study examines the effects of the APOE ε4 gene variant, which is known to increase the risk of developing Alzheimer's. By using mouse models, researchers aim to uncover how changes in microglial signaling can influence disease progression and potentially restore protective functions in the brain. The findings could lead to new therapeutic strategies for managing Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to Alzheimer's disease, particularly those carrying the APOE ε4 allele.
Not a fit: Patients without any genetic risk factors for Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help protect brain function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting microglial signaling pathways in neurodegenerative diseases, indicating that this approach may be effective.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Butovsky, Oleg — Brigham and Women's Hospital
- Study coordinator: Butovsky, Oleg
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.