Investigating how APOBEC mutations affect breast cancer progression
APOBEC MUTAGENESIS IN BREAST CANCER
This study is looking at how certain changes in genes called APOBEC might affect breast cancer, especially in patients with estrogen receptor-positive breast cancer, and it hopes to find new ways to slow down the disease and improve treatment outcomes for those affected.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10738334 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of APOBEC mutations in breast cancer, particularly how these mutations contribute to the development and progression of the disease. The study aims to quantify APOBEC activity in tumor cells and explore the potential of inhibiting this activity to reduce further mutations in estrogen receptor-positive breast cancer. By examining the relationship between APOBEC levels and clinical outcomes, the research seeks to improve treatment durability and patient survival rates. Patients may benefit from new therapeutic strategies that target these mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with estrogen receptor-positive breast cancer, particularly those with operable disease or recurrent metastases.
Not a fit: Patients with other types of breast cancer or those who do not express estrogen receptors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better survival outcomes for patients with breast cancer.
How similar studies have performed: Previous research has indicated that targeting mutagenesis in cancer cells can lead to improved treatment outcomes, suggesting that this approach may hold promise.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Harris, Reuben S — University of Texas Hlth Science Center
- Study coordinator: Harris, Reuben S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.