Investigating how Apelin affects heart function in pulmonary hypertension
The emerging role of apelin, RAAS, and ACE2 crosstalk in pulmonary hypertension
This study is looking at how a substance called Apelin might help protect the heart from problems caused by pulmonary hypertension, with the hope of finding new treatments for people dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10876445 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Apelin, a peptide, in preventing right ventricular failure associated with pulmonary hypertension (PH). The team will explore whether Apelin can protect the heart by influencing the Renin-Angiotensin-Aldosterone System (RAAS) and activating ACE2, a key enzyme. By using various cell types, including human stem cell-derived heart cells, the researchers aim to uncover the mechanisms through which Apelin may improve heart function and reduce the harmful effects of PH. This could lead to new therapeutic strategies for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension, particularly those experiencing right ventricular dysfunction.
Not a fit: Patients without pulmonary hypertension or those whose heart function is not affected by this condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and outcomes for patients with pulmonary hypertension.
How similar studies have performed: While the specific approach of targeting Apelin in pulmonary hypertension is novel, similar studies have shown promise in exploring the roles of RAAS and ACE2 in heart conditions.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Frump, Andrea Lee — Indiana University Indianapolis
- Study coordinator: Frump, Andrea Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.