Investigating how antiviral medications affect hormone levels in pregnant individuals and their babies
Understanding the underlying toxicological mechanisms of drug-hormone interactions to improve the safety profile of antiviral medications in pregnant people, developing fetuses, and neonates
This study is looking at how antiviral medications might affect hormone levels in pregnant people and their babies, with the goal of making these treatments safer for everyone involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11026399 on NIH RePORTER |
What this research studies
This research focuses on understanding the toxic effects that antiviral medications can have on hormone levels in pregnant individuals, their developing fetuses, and newborns. It aims to identify the mechanisms behind drug-hormone interactions that may lead to adverse health outcomes, such as low birth weight and neurodevelopmental issues. By studying the enzymes involved in drug metabolism and hormone regulation, the research seeks to improve the safety of antiviral therapies for these vulnerable populations. Patients may be involved in discussions about their experiences with antiviral treatments during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals receiving antiviral therapy and their newborns.
Not a fit: Patients who are not pregnant or those not receiving antiviral medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer antiviral medications for pregnant individuals and their children.
How similar studies have performed: Previous research has indicated that understanding drug-hormone interactions can lead to improved safety profiles for medications, suggesting potential success for this approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Lampe, Jed Noah — University of Colorado Denver
- Study coordinator: Lampe, Jed Noah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.