Investigating how antidepressants work in the brain to help treat depression in veterans.
BLRD Research Career Scientist Award Application
This study is looking at how antidepressant medications work in the brains of veterans and active-duty military members with depression, hoping to find clues that could help make treatments faster and more effective for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10951544 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms by which antidepressant medications affect brain cells, particularly in veterans and active-duty military personnel suffering from depression. It aims to identify a cellular 'biosignature' that could indicate how effective these medications are and why some patients do not respond to treatment. By examining the behavior of specific proteins in brain cells after antidepressant treatment, the study hopes to uncover new insights that could lead to faster-acting and more effective therapies for depression. The research will utilize both cultured cells and post-mortem tissue samples to explore these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include veterans and active-duty military personnel who are experiencing symptoms of depression.
Not a fit: Patients who do not have a diagnosis of depression or who are not veterans or active-duty military personnel may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antidepressant treatments with quicker onset of relief for patients suffering from depression.
How similar studies have performed: Previous research has shown promising results in understanding the cellular mechanisms of antidepressants, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, United States
- Jesse Brown VA Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Rasenick, Mark M. — Jesse Brown VA Medical Center
- Study coordinator: Rasenick, Mark M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.