Investigating how antidepressants affect HIV persistence and inflammation in the body
Official title: The role of antidepressants in central and peripheral myeloid HIV persistence and inflammation
Funded at Drexel University · NIH-11094813 · Data updated 2026-11-12
This study is looking at how antidepressants might affect HIV and inflammation in the body, especially in certain immune cells, to help improve treatment for people living with HIV who also deal with depression.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $185,220 |
| NIH project number | 5K01MH132466-03 |
| Project ID | NIH-11094813 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV who are also experiencing symptoms of depression.
✕Less likely to help
Patients who do not have HIV or those who are not experiencing depression may not benefit from this research.
What this research studies
This research focuses on understanding the impact of antidepressants on HIV viral dynamics and inflammation in the body, particularly in myeloid cells, which are key players in HIV infection. The study employs advanced techniques to analyze how these medications may influence the behavior of HIV and related inflammatory processes. By examining clinical cohorts and utilizing biostatistical analyses, the research aims to uncover the relationship between depression, HIV persistence, and neurological complications. This work is part of a broader effort to improve treatment outcomes for individuals living with HIV.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for HIV patients, particularly those experiencing depression, potentially enhancing their overall health and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the interplay between mental health and HIV treatment, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Drexel University
Philadelphia, United States Active
Researchers
- Principal investigator: Matt, Stephanie Marie — Drexel University
- Study coordinator: Matt, Stephanie Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.