Investigating how antibodies interact with immune cells to combat HIV
Antiviral Activity In Situ
This study is looking at how certain antibodies can help immune cells better fight HIV, and it's for anyone interested in improving treatments and vaccines for HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10894668 on NIH RePORTER |
What this research studies
This research focuses on understanding how anti-HIV antibodies interact with various immune cells to enhance their ability to fight the virus. By examining the mechanisms of antibody-dependent cell phagocytosis and cytotoxicity, the study aims to identify how these processes can be optimized for better protection against HIV. The research involves both human and non-human primate studies to explore the effectiveness of different antibody subclasses and their roles in early viral replication. Insights gained from this research could lead to improved vaccination strategies and therapeutic approaches for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for HIV infection or those living with HIV who are seeking new treatment options.
Not a fit: Patients who are not at risk for HIV or those who are already receiving effective treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and treatments for HIV, improving patient outcomes.
How similar studies have performed: Previous studies have shown promising results in using antibody-mediated approaches to enhance immune responses against HIV, indicating potential for success in this research.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Tomaras, Georgia Doris — Duke University
- Study coordinator: Tomaras, Georgia Doris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.