Investigating how antibodies help Zika virus cross the placenta
Understanding the mechanisms of antibody-mediated transcytosis of ZIKV within the placenta
This study is looking at how antibodies in pregnant women can help the Zika virus cross the placenta, which might affect the health of their babies, and it hopes to find ways to improve outcomes for pregnancies impacted by this virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10835913 on NIH RePORTER |
What this research studies
This research focuses on understanding how antibodies interact with the Zika virus (ZIKV) to facilitate its movement across the placenta. By examining the mechanisms of antibody-mediated transcytosis, the study aims to uncover how prior exposure to related viruses may influence ZIKV infection outcomes in pregnant women. The research involves analyzing the immune response and the structural characteristics of the placenta to determine how ZIKV can cause congenital malformations. This could lead to better understanding and potential interventions for affected pregnancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who have been exposed to Zika virus or related flaviviruses.
Not a fit: Patients who are not pregnant or have not been exposed to Zika virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing Zika virus transmission during pregnancy and reducing the risk of congenital defects.
How similar studies have performed: Previous research has shown that understanding antibody interactions with viruses can lead to significant advancements in treatment and prevention strategies, indicating potential success for this approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Suthar, Mehul Shamal — Emory University
- Study coordinator: Suthar, Mehul Shamal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.