Investigating how angiotensin II affects bladder function and pain
Role of Angiotensin II in Bladder Dysfunction
This study is looking at how a substance called angiotensin II might be affecting bladder problems, like the pain and frequent trips to the bathroom that people with interstitial cystitis or bladder pain syndrome experience, to find new ways to help those who are struggling with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11095328 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of angiotensin II (Ang II) in bladder dysfunction, particularly in conditions like interstitial cystitis/bladder pain syndrome (IC/BPS). It aims to explore how Ang II contributes to symptoms such as increased voiding frequency, bladder fibrosis, and chronic pelvic pain. By examining the signaling pathways and inflammatory responses associated with Ang II, the study seeks to identify potential new treatment targets for patients suffering from these debilitating bladder conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with interstitial cystitis/bladder pain syndrome (IC/BPS) who experience chronic pelvic pain and other related symptoms.
Not a fit: Patients who do not have bladder dysfunction or those with other unrelated urinary conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for bladder dysfunction and pain, improving the quality of life for affected patients.
How similar studies have performed: While the role of angiotensin II in other organ systems has been studied, this specific investigation into its effects on bladder dysfunction is relatively novel and has not been extensively tested.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Mickle, Aaron David — Medical College of Wisconsin
- Study coordinator: Mickle, Aaron David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.