Investigating how androgens affect ovarian follicle development
Paxillin and Androgens in the Regulation of Ovarian Follicle Development
This study is looking at how certain hormones called androgens affect the growth of ovarian follicles, which are important for fertility, especially in women dealing with conditions like PCOS or diminished ovarian reserve, and it uses mice to see how a specific protein impacts this process to help find better treatments for infertility.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10897087 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of androgens in the development of ovarian follicles, which are crucial for female fertility. It aims to uncover the molecular pathways that are disrupted in conditions like polycystic ovary syndrome (PCOS) and diminished ovarian reserve (DOR). The study will utilize a mouse model to examine how the loss of a protein called paxillin affects follicle growth and overall fertility. By exploring these mechanisms, the research seeks to provide insights that could lead to better treatments for infertility related to androgen imbalances.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing infertility linked to conditions such as polycystic ovary syndrome (PCOS) or diminished ovarian reserve (DOR).
Not a fit: Patients who do not have issues related to androgen imbalance or those not experiencing infertility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for women suffering from infertility due to androgen-related disorders.
How similar studies have performed: While the specific approach of examining paxillin's role in ovarian granulosa cells is novel, previous research has shown success in understanding androgen effects in other reproductive contexts.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Astapova, Olga — University of Rochester
- Study coordinator: Astapova, Olga
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.