Investigating how androgen signaling affects prostate cancer development
Official title: A new and non-autonomous role of androgen signaling in prostate tumorigenesis
Funded at Albert Einstein College of Medicine · NIH-11030922 · Data updated 2026-11-12
This study is looking at how hormones called androgens affect prostate cancer growth, especially when standard treatments aren't working, to find new ways to help patients with advanced prostate cancer feel better and live longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $535,334 |
| NIH project number | 1R01CA289319-01A1 |
| Project ID | NIH-11030922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are American men diagnosed with advanced prostate cancer, particularly those who have developed resistance to androgen deprivation therapy.
✕Less likely to help
Patients with early-stage prostate cancer or those who have not undergone androgen deprivation therapy may not benefit from this research.
What this research studies
This research explores the role of androgen signaling, particularly through the androgen receptor, in the development of prostate cancer. It aims to understand how androgen signaling in the surrounding stromal cells influences the growth of prostate tumors, especially in cases where traditional androgen deprivation therapies fail. By examining the interactions between prostate epithelial cells and their stromal environment, the study seeks to uncover new therapeutic strategies for advanced prostate cancer. Patients may benefit from insights that could lead to more effective treatments for those with castration-resistant prostate cancer.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with advanced prostate cancer who do not respond to current therapies.
How similar studies have gone: Other research has shown promising results in understanding the role of stromal interactions in cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Sun, Zijie — Albert Einstein College of Medicine
- Study coordinator: Sun, Zijie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.