Investigating how androgen receptors affect T cell function and cancer treatment
Understanding how T cell intrinsic androgen receptor activity influences cell differentiation and dysfunction
This study is looking at how certain receptors in immune cells called T cells affect cancer treatment, especially in men with advanced prostate cancer, to see if lowering these receptors can help improve their response to immunotherapy.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10893432 on NIH RePORTER |
What this research studies
This research explores the role of androgen receptors in T cell differentiation and dysfunction, particularly in the context of cancer immunotherapy. It examines how low androgen receptor activity in CD8 T cells correlates with better responses to immunotherapy in patients with metastatic prostate cancer. The study utilizes mouse models and patient biopsies to understand the mechanisms behind T cell responses and the potential for enhancing immunotherapy effectiveness through androgen receptor inhibition. By isolating activated CD8 T cells, researchers aim to identify how androgen receptors interact with chromatin modifiers and influence immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with metastatic prostate cancer who are undergoing immunotherapy.
Not a fit: Patients with cancers unrelated to androgen receptor activity or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer immunotherapy strategies, particularly for patients with prostate cancer.
How similar studies have performed: Previous research has shown promising results in targeting androgen receptors to enhance immunotherapy, indicating a potential for success in this approach.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Moran, Amy E — Oregon Health & Science University
- Study coordinator: Moran, Amy E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.