Investigating how androgen receptors affect melanoma
Androgen receptor function in melanoma
This study is looking at how hormones related to sex might affect the growth of melanoma, a type of skin cancer, and how blocking certain hormone signals could lead to better treatments and outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10914195 on NIH RePORTER |
What this research studies
This research explores the role of androgen receptors and associated proteins in the development and treatment response of melanoma, a type of skin cancer. The study aims to understand how sex hormone levels influence melanoma progression and patient outcomes. Researchers will investigate the effects of suppressing androgen receptor activity on melanoma cells, focusing on its impact on tumor growth and DNA repair mechanisms. By examining these interactions, the research seeks to identify potential new treatment strategies that could improve survival rates for patients with melanoma.
Who could benefit from this research
Good fit: Ideal candidates for this research include melanoma patients, particularly those with varying levels of androgen receptor activity.
Not a fit: Patients with melanoma who do not express androgen receptors or have other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that enhance survival rates for melanoma patients.
How similar studies have performed: Previous research has shown promising results in targeting androgen receptors in other cancers, suggesting potential for success in this area as well.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dotto, Gian-Paolo — Massachusetts General Hospital
- Study coordinator: Dotto, Gian-Paolo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.