Investigating how an enzyme affects melanoma progression
Impact of N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B) on the Progression of Melanoma
This study is looking at how a specific enzyme, which is important for fighting melanoma, works and why lower levels of it might make the cancer more aggressive, with the goal of finding new ways to help patients with melanoma feel better and live longer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10881735 on NIH RePORTER |
What this research studies
This research focuses on the role of the enzyme N-acetylgalactosamine-4-sulfatase, also known as arylsulfatase B, in the progression of melanoma. The study aims to understand how lower levels of this enzyme are linked to more aggressive forms of melanoma and how it influences the expression of proteins that affect tumor growth and survival. By examining the mechanisms behind these changes, the research seeks to identify new treatment strategies that could improve outcomes for patients with melanoma. The approach includes laboratory experiments to analyze melanoma cells and their responses to various treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with melanoma, particularly those who have not responded well to existing treatments.
Not a fit: Patients with early-stage melanoma or those who have not yet begun treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve treatment outcomes for melanoma patients.
How similar studies have performed: Other research has shown promising results in targeting similar pathways in melanoma treatment, indicating potential for success with this approach.
Where this research is happening
Chicago, United States
- Jesse Brown VA Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Tobacman, Joanne Kramer — Jesse Brown VA Medical Center
- Study coordinator: Tobacman, Joanne Kramer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.