Investigating how an enzyme affects blood-brain barrier function in the brain
The role of tissue nonspecific alkaline phosphatase in brain endothelial cell homeostasis
This study is looking at how a specific enzyme called TNAP helps keep the brain's protective barrier healthy, especially as we age or after a stroke, using mice to learn more about how it can prevent problems that affect brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project ID | NIH-11076757 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of tissue nonspecific alkaline phosphatase (TNAP) in maintaining the health of brain endothelial cells, which are crucial for the blood-brain barrier. The study will use mouse models to explore how TNAP activity influences cerebrovascular function, particularly in the context of aging and after events like stroke. By comparing young and aged mice, the research aims to uncover the mechanisms by which TNAP protects the integrity of the blood-brain barrier and prevents increased permeability that can lead to neurological issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults or individuals who have experienced a stroke, particularly those with concerns about cerebrovascular health.
Not a fit: Patients who are younger and do not have any cerebrovascular conditions or risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for protecting the brain's blood supply and preventing damage after strokes or in age-related conditions.
How similar studies have performed: While the specific role of TNAP in brain endothelial cells is less explored, similar studies have shown that targeting endothelial cell function can significantly improve outcomes in cerebrovascular diseases.
Where this research is happening
Morgantown, United States
- West Virginia University — Morgantown, United States (Active)
Researchers
- Principal investigator: Brown, Candice — West Virginia University
- Study coordinator: Brown, Candice
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.