Investigating how an anti-inflammatory diet affects gut health in Crohn's disease
Effect of an Anti-Inflammatory Diet on Gut Homeostasis in Active and Experimental Crohn's Disease
This study is looking at how eating an anti-inflammatory diet, especially with soy and amino acids, can help improve gut health for people with active Crohn's disease, and it will also compare these effects to those in healthy individuals to see how different people respond to these dietary changes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11000387 on NIH RePORTER |
What this research studies
This research explores the impact of an anti-inflammatory diet, particularly focusing on dietary soy and amino acid supplementation, on gut health in patients with active Crohn's disease. The study aims to understand how these dietary changes can influence gut microbiota and immune responses, potentially leading to improved management of the disease. By comparing the effects in Crohn's disease patients to healthy individuals, the research seeks to identify specific biomarkers that predict individual responses to dietary interventions. Participants will be monitored for changes in their gut microbiome and metabolic functions as a result of the dietary modifications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with active Crohn's disease who are looking for dietary interventions to manage their condition.
Not a fit: Patients with other gastrointestinal disorders or those who are not currently experiencing active symptoms of Crohn's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized dietary recommendations that improve gut health and reduce inflammation in Crohn's disease patients.
How similar studies have performed: Previous research has shown promising results in using dietary interventions to modulate gut microbiota, suggesting that this approach may be effective for Crohn's disease as well.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Raffner, Abigail — Case Western Reserve University
- Study coordinator: Raffner, Abigail
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.