Investigating how amyloid precursor protein processing affects Alzheimer's disease
Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease
['FUNDING_OTHER'] · BROAD INSTITUTE, INC. · NIH-10987064
This study is looking at how a protein related to Alzheimer's disease behaves in live human brain cells, using special imaging tools, to help us understand how changes in this protein might affect brain function and lead to the disease, which could help in finding new treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROAD INSTITUTE, INC. (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10987064 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of amyloid precursor protein (APP) processing in Alzheimer's disease by using advanced imaging techniques. Researchers will utilize novel photostable nanoparticles to observe the behavior of APP in live human neurons, which may provide insights into how mutations affect neuronal function and contribute to the disease. By tracking the movement and processing of APP at a single-molecule level, the study aims to fill critical gaps in our understanding of Alzheimer's pathology and potential treatment avenues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, including those with a family history or genetic predispositions.
Not a fit: Patients with advanced Alzheimer's disease or those who do not have any genetic risk factors for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the mechanisms of APP processing.
How similar studies have performed: While the approach of using advanced imaging techniques is innovative, similar studies have shown promise in understanding Alzheimer's disease mechanisms, suggesting potential for success.
Where this research is happening
CAMBRIDGE, UNITED STATES
- BROAD INSTITUTE, INC. — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENG, CHUNTE — BROAD INSTITUTE, INC.
- Study coordinator: PENG, CHUNTE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer disease prevention, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease patient