Investigating how amyloid deposits affect brain plasticity in Alzheimer's disease
Cell-specific plasticity pathway dysfunction as a result of amyloid deposition in Alzheimer's Disease
['FUNDING_OTHER'] · VA BOSTON HEALTH CARE SYSTEM · NIH-11003962
This study is looking at how sticky proteins in the brain, called amyloid deposits, affect memory and thinking in veterans with Alzheimer's, and it hopes to find new ways to help improve brain function.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA BOSTON HEALTH CARE SYSTEM (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11003962 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how amyloid deposits in the brain contribute to cognitive decline in Alzheimer's disease, particularly in veterans. It aims to identify specific cellular changes and dysfunctions in brain pathways that are crucial for learning and memory. By examining the relationship between amyloid accumulation and alterations in neuronal function, the study seeks to uncover potential targets for future therapies that could restore cognitive function. The research employs advanced techniques to analyze brain circuits and their ability to adapt over time.
Who could benefit from this research
Good fit: Ideal candidates for this research include veterans diagnosed with Alzheimer's disease or those experiencing cognitive decline associated with amyloid pathology.
Not a fit: Patients without a diagnosis of Alzheimer's disease or those not affected by amyloid-related cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of amyloid in cognitive dysfunction, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- VA BOSTON HEALTH CARE SYSTEM — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMIRNAKIS, STELIOS MANOLIS — VA BOSTON HEALTH CARE SYSTEM
- Study coordinator: SMIRNAKIS, STELIOS MANOLIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease model