Investigating how amyloid-beta proteins spread in Alzheimer's disease
Role of circulating Abeta seeds and peripheral tissue damage in Alzheimer's disease pathogenesis
This study is looking at how certain proteins related to Alzheimer's disease move through the blood and affect the body, with the goal of finding new ways to diagnose and treat the disease for people living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10875740 on NIH RePORTER |
What this research studies
This research explores the role of amyloid-beta (Aβ) proteins in the development of Alzheimer's disease by examining how these proteins spread through the blood and affect peripheral tissues. The study aims to identify and characterize biologically active Aβ aggregates found in the blood of Alzheimer's patients, which may contribute to the progression of the disease. By understanding the mechanisms of Aβ spread and clearance, the research seeks to develop new diagnostic and therapeutic strategies targeting these aggregates. The approach includes using animal models and advanced laboratory techniques to analyze the presence and impact of Aβ in the bloodstream.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease who exhibit symptoms related to amyloid-beta accumulation.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to amyloid-beta pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and treatment options for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of amyloid-beta in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Soto, Claudio — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Soto, Claudio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.