Investigating how amyloid beta interacts with collagen in the brain's blood vessels in Alzheimer's disease
Official title: Amyloid Beta and Collagen IV Interactions in the Brain Microvasculature in Alzheimers Disease
Funded at University of Washington · NIH-11099893 · Data updated 2026-11-12
This study is looking at how a protein linked to Alzheimer's disease interacts with a type of collagen in the brain's tiny blood vessels, which could help us understand how these interactions might lead to problems like bleeding in the brain and find new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $671,255 |
| NIH project number | 5R01AG087226-02 |
| Project ID | NIH-11099893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related conditions, particularly those experiencing early microvascular changes.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any signs of microvascular changes may not benefit from this research.
What this research studies
This research explores the interactions between amyloid beta and collagen IV in the brain's microvasculature, which are crucial for understanding Alzheimer's disease. The study aims to identify how these interactions affect the structural integrity of blood vessels and contribute to complications like microhemorrhages. Using advanced imaging techniques and mouse models, researchers will analyze brain tissue to uncover the spatial relationships between amyloid beta and collagen IV. This could lead to insights into the mechanisms of Alzheimer's disease and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the interactions between amyloid beta and collagen IV.
How similar studies have gone: While the specific interactions being studied are not well-explored, related research has shown promising results in understanding amyloid beta's role in Alzheimer's disease.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Reed, May J — University of Washington
- Study coordinator: Reed, May J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.