Investigating how amyloid beta affects immune response in brain cancer
Official title: Targeting amyloid beta for myeloid reprogramming in brain metastasis
Funded at New York University School of Medicine · NIH-10826697 · Data updated 2026-11-12
This study is looking at how a protein related to Alzheimer's disease affects the immune system in the brains of cancer patients, and it hopes to find ways to boost the immune response to help fight brain tumors better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 1F30CA288047-01 |
| Project ID | NIH-10826697 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with advanced-stage cancer who have developed brain metastases.
✕Less likely to help
Patients with early-stage cancer or those without brain metastases may not benefit from this research.
What this research studies
This research focuses on understanding the role of amyloid beta, a protein linked to Alzheimer's disease, in the immune response of brain metastases from cancer. The researchers will use mouse models to explore how amyloid beta contributes to immunosuppression in the brain environment, which can hinder effective cancer treatment. By targeting amyloid beta with specific inhibitors, the study aims to reprogram immune cells called macrophages to enhance their ability to fight tumors. This approach could lead to more effective therapies for patients with brain metastases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve immune responses against brain tumors in cancer patients.
How similar studies have gone: Previous studies have shown promise in targeting amyloid beta for enhancing immune responses in other contexts, suggesting potential for success in this novel application.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Eskow, Nicole Marie — New York University School of Medicine
- Study coordinator: Eskow, Nicole Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.