Investigating how amyloid beta affects brain signaling in Alzheimer's disease
Postsynaptic kinase/phosphatase networks in amyloid beta-induced synaptic dysfunction
This study is looking at how a protein linked to Alzheimer's disease affects brain connections that are important for learning and memory, using mice to find out how it disrupts these connections and what we might be able to do to help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10811523 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms by which amyloid beta, a protein associated with Alzheimer's disease, disrupts synaptic function in the brain. It examines how this disruption affects learning and memory by studying the signaling pathways involved in synaptic plasticity, particularly the roles of specific proteins that regulate the movement of receptors at synapses. The research utilizes mouse models of Alzheimer's to observe changes in synaptic signaling and receptor trafficking in response to amyloid beta exposure. By identifying these mechanisms, the research aims to uncover potential targets for therapeutic intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it due to genetic factors.
Not a fit: Patients with other forms of dementia unrelated to amyloid beta pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore synaptic function and improve cognitive abilities in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding synaptic dysfunction in Alzheimer's disease, indicating that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Dell'acqua, Mark L — University of Colorado Denver
- Study coordinator: Dell'acqua, Mark L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.