Investigating how amyloid beta affects brain function in Alzheimer's disease
Official title: APP as a mediator of amyloid beta effects on CaMKII synaptic functions
Funded at University of Colorado Denver · NIH-10928133 · Data updated 2026-11-12
This study is looking at how a protein linked to Alzheimer's disease affects brain functions important for learning and memory, with the hope of finding new ways to help people with Alzheimer's.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 3, 2023 |
| Project end | August 2, 2026 |
| Funding year | 2024 |
| Award (this year) | $38,434 |
| NIH project number | 5F31AG084197-02 |
| Project ID | NIH-10928133 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with other forms of dementia unrelated to amyloid beta pathology may not benefit from this research.
What this research studies
This research explores the role of amyloid beta, a protein associated with Alzheimer's disease, in disrupting synaptic functions crucial for learning and memory. By examining how amyloid beta impacts a specific protein called CaMKII in the brain's hippocampus, the study aims to uncover mechanisms that lead to cognitive decline in Alzheimer's patients. The research utilizes ex vivo hippocampal slices to analyze the effects of amyloid beta on synaptic strengthening processes. Understanding these interactions may provide insights into potential therapeutic targets for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of amyloid beta in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Larsen, Matthew E — University of Colorado Denver
- Study coordinator: Larsen, Matthew E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.