Investigating how amyloid-beta affects aging cells in Alzheimer's disease
AMYLOIDOGENIC INDUCTION OF CELLULAR SENESCENCE IN ALZHEIMER'S DISEASE
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10888177
This study is looking at how certain proteins related to Alzheimer's disease might cause brain cells to stop working properly, which could help us understand more about how Alzheimer's develops and progresses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10888177 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between amyloid-beta oligomers, a key feature of Alzheimer's disease, and cellular senescence, which is the process where cells lose the ability to divide. By using advanced techniques, the study aims to understand how these amyloid-beta proteins can induce senescence in brain cells, potentially linking them to the progression of Alzheimer's. The researchers will analyze genetic and epigenetic changes in these cells to uncover the mechanisms at play. This could lead to new insights into how Alzheimer's disease develops and progresses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target cellular senescence in Alzheimer's disease, potentially slowing its progression.
How similar studies have performed: While the specific approach of linking amyloid-beta to cellular senescence is novel, related research has shown promising results in understanding the role of amyloid-beta in Alzheimer's disease.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MIRANKER, ANDREW D. — YALE UNIVERSITY
- Study coordinator: MIRANKER, ANDREW D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome