Investigating how amyloid-β affects blood flow control in the brain
Official title: Amyloid-β Disruption of Pericyte Control of Capillary Hemodynamics
Funded at University of Nevada Reno · NIH-11076650 · Data updated 2026-11-12
This study is looking at how a protein linked to Alzheimer's disease affects certain brain cells that help control blood flow, with the hope of finding ways to improve blood flow and support brain health for older adults facing cognitive decline.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $499,103 |
| NIH project number | 5R01AG081935-03 |
| Project ID | NIH-11076650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or have been diagnosed with it.
✕Less likely to help
Patients who are not affected by Alzheimer's disease or related cognitive impairments may not benefit from this research.
What this research studies
This research focuses on understanding the role of amyloid-β, a protein associated with Alzheimer's disease, in disrupting the function of pericytes, which are cells that help regulate blood flow in the brain's capillaries. By examining how amyloid-β affects these cells, the research aims to uncover the mechanisms behind vascular dysfunction in Alzheimer's disease. The study employs advanced imaging techniques to observe changes in blood flow and cellular responses in the brain, particularly in aging adults. The findings could provide insights into how to improve blood flow and nutrient delivery to brain cells, potentially slowing the progression of cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance brain blood flow and improve cognitive function in patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between vascular health and Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Gonzales, Albert Louis — University of Nevada Reno
- Study coordinator: Gonzales, Albert Louis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.