Investigating how AMPK functions in Alzheimer's Disease
AMPK localization, expression, and activity in Alzheimer's Disease
This study is looking at how a protein called AMPK behaves in the brains of people aged 65 and older with Alzheimer's Disease, hoping to find new ways to understand and treat the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project ID | NIH-10894811 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of adenosine monophosphate activated protein kinase (AMPK) in Alzheimer's Disease (AD), particularly in individuals aged 65 and older. The study aims to explore how AMPK's localization, expression, and activity change in the brains of those affected by AD. By examining these cellular mechanisms, the research seeks to uncover new insights into the metabolic disturbances that contribute to neurodegeneration in Alzheimer's. This could lead to a better understanding of the disease and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are diagnosed with Alzheimer's Disease.
Not a fit: Patients under the age of 65 or those without a diagnosis of Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into Alzheimer's Disease that may lead to the development of effective treatments.
How similar studies have performed: While the role of AMPK in Alzheimer's has been suggested in pre-clinical studies, this specific investigation into its localization and activity in human brains is relatively novel.
Where this research is happening
Toledo, United States
- University of Toledo Health Sci Campus — Toledo, United States (Active)
Researchers
- Principal investigator: Henkel, Nicholas Daniel — University of Toledo Health Sci Campus
- Study coordinator: Henkel, Nicholas Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.