Investigating how AMPK and CD36 affect the spread of breast cancer
Official title: The role of AMPK and CD36 in breast cancer metastasis
Funded at Jesse Brown VA Medical Center · NIH-11048353 · Data updated 2026-11-12
This study is looking at how certain proteins in the body can affect the spread of breast cancer, especially when someone is on a high-fat diet, and it hopes to find new ways to help patients by targeting these proteins.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 2I01BX005092-05 |
| Project ID | NIH-11048353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with breast cancer, particularly those with a high risk of metastasis.
✕Less likely to help
Patients with non-breast cancer-related conditions or those whose cancer has already metastasized extensively may not benefit from this research.
What this research studies
This research explores the mechanisms by which the proteins AMPK and CD36 influence the metastasis of breast cancer. It examines how a high-fat diet can increase cancer spread and how targeting CD36 may inhibit this process. The study utilizes mouse models to understand the role of these proteins in tumor growth and survival, aiming to identify potential therapeutic strategies for patients with breast cancer. By focusing on the relationship between fatty acid transport and cancer progression, the research seeks to uncover new treatment avenues.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively reduce breast cancer metastasis and improve patient survival rates.
How similar studies have gone: Other research has shown promising results in targeting metabolic pathways in cancer treatment, suggesting that this approach may also yield beneficial outcomes.
Where this research is happening
-
Jesse Brown VA Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Hay, Nissim — Jesse Brown VA Medical Center
- Study coordinator: Hay, Nissim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.