Investigating how AMPK and CD36 affect the spread of breast cancer
The role of AMPK and CD36 in breast cancer metastasis
['FUNDING_OTHER'] · JESSE BROWN VA MEDICAL CENTER · NIH-11048353
This study is looking at how certain proteins in the body can affect the spread of breast cancer, especially when someone is on a high-fat diet, and it hopes to find new ways to help patients by targeting these proteins.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JESSE BROWN VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11048353 on ClinicalTrials.gov |
What this research studies
This research explores the mechanisms by which the proteins AMPK and CD36 influence the metastasis of breast cancer. It examines how a high-fat diet can increase cancer spread and how targeting CD36 may inhibit this process. The study utilizes mouse models to understand the role of these proteins in tumor growth and survival, aiming to identify potential therapeutic strategies for patients with breast cancer. By focusing on the relationship between fatty acid transport and cancer progression, the research seeks to uncover new treatment avenues.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with breast cancer, particularly those with a high risk of metastasis.
Not a fit: Patients with non-breast cancer-related conditions or those whose cancer has already metastasized extensively may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively reduce breast cancer metastasis and improve patient survival rates.
How similar studies have performed: Other research has shown promising results in targeting metabolic pathways in cancer treatment, suggesting that this approach may also yield beneficial outcomes.
Where this research is happening
CHICAGO, UNITED STATES
- JESSE BROWN VA MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAY, NISSIM — JESSE BROWN VA MEDICAL CENTER
- Study coordinator: HAY, NISSIM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Breast Cancer Cell