Investigating how AMPA receptors are transported in the nervous system
In Vivo Investigations of AMPA receptor transport
This study is looking at how certain important proteins, called AMPA receptors, move around in brain cells to help with learning and memory, using tiny worms to see how these proteins work in real-time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-11072962 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms that control the transport of AMPA receptors, which are crucial for synaptic function and cognitive processes. Using the model organism C. elegans, the study employs advanced microscopy techniques to observe and manipulate the transport of these receptors in real-time within living neuronal circuits. By examining how these receptors are delivered and removed from synapses, the research aims to uncover the cellular processes that maintain synaptic health and plasticity, which are vital for learning and memory.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cognitive impairments or neurological conditions that may be linked to synaptic dysfunction.
Not a fit: Patients with conditions unrelated to synaptic transmission or those who do not exhibit cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cognitive disorders and potential therapeutic targets for conditions affecting synaptic function.
How similar studies have performed: While the specific approach using C. elegans for real-time observation of AMPA receptor transport is novel, similar studies in other models have shown promising results in understanding synaptic mechanisms.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Hoerndli, Frederic J — Colorado State University
- Study coordinator: Hoerndli, Frederic J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.