Investigating how AMP-kinase affects kidney disease transitions
Role of AMP-kinase pathway in the regulation of Minimal change disease-to-FSGS transition
This study is looking at how certain proteins in the kidneys affect the health of important cells called podocytes, which can help us understand why some people with nephrotic syndrome go from having a mild form of the disease to a more serious one, and it involves both human samples and mice to find ways to keep these cells healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10978223 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind nephrotic syndrome, particularly the transition from Minimal Change Disease (MCD) to Focal Segmental Glomerulosclerosis (FSGS). It examines the role of AMP-kinase and Fyn kinase in podocyte health, which are crucial cells in the kidneys. By studying these pathways, the research aims to identify signals that help maintain podocyte survival and prevent disease progression. The approach includes both human samples and mouse models to explore these cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and young children under one year of age who are diagnosed with nephrotic syndrome.
Not a fit: Patients with advanced kidney disease or those who do not have nephrotic syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the progression of kidney diseases in affected patients.
How similar studies have performed: Previous research has shown promising results in understanding similar pathways in kidney diseases, suggesting potential for success in this investigation.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Menon, Madhav C — Yale University
- Study coordinator: Menon, Madhav C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.