Investigating how Aminopeptidase N affects signaling in pulmonary hypertension
Aminopeptidase N Driven Signaling in the Development of Pulmonary Hypertension
This study is looking at how a specific enzyme called Aminopeptidase N affects the way our cells communicate in pulmonary hypertension, a condition that impacts the blood vessels in the lungs, with the hope that what we learn could help develop better treatments for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11081663 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Aminopeptidase N in the signaling pathways that contribute to pulmonary hypertension, a serious condition affecting blood vessels in the lungs. The project aims to explore mitochondrial dysfunction and its relationship with this enzyme, utilizing advanced techniques such as single-cell transcriptomics and co-culture methods. Patients may benefit from insights gained through this research, which could lead to new therapeutic strategies for managing pulmonary hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension or those at risk for developing this condition.
Not a fit: Patients with pulmonary hypertension caused by factors unrelated to mitochondrial dysfunction or Aminopeptidase N may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with pulmonary hypertension.
How similar studies have performed: While the specific focus on Aminopeptidase N in pulmonary hypertension is novel, related research on mitochondrial dysfunction has shown promise in understanding and treating various cardiovascular conditions.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: James, Joel — Indiana University Indianapolis
- Study coordinator: James, Joel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.