Investigating how Aminopeptidase N affects signaling in pulmonary hypertension
Official title: Aminopeptidase N Driven Signaling in the Development of Pulmonary Hypertension
Funded at Indiana University Indianapolis · NIH-11081663 · Data updated 2026-11-12
This study is looking at how a specific enzyme called Aminopeptidase N affects the way our cells communicate in pulmonary hypertension, a condition that impacts the blood vessels in the lungs, with the hope that what we learn could help develop better treatments for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $102,403 |
| NIH project number | 5K99HL171869-02 |
| Project ID | NIH-11081663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary hypertension or those at risk for developing this condition.
✕Less likely to help
Patients with pulmonary hypertension caused by factors unrelated to mitochondrial dysfunction or Aminopeptidase N may not benefit from this research.
What this research studies
This research focuses on understanding the role of Aminopeptidase N in the signaling pathways that contribute to pulmonary hypertension, a serious condition affecting blood vessels in the lungs. The project aims to explore mitochondrial dysfunction and its relationship with this enzyme, utilizing advanced techniques such as single-cell transcriptomics and co-culture methods. Patients may benefit from insights gained through this research, which could lead to new therapeutic strategies for managing pulmonary hypertension.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with pulmonary hypertension.
How similar studies have gone: While the specific focus on Aminopeptidase N in pulmonary hypertension is novel, related research on mitochondrial dysfunction has shown promise in understanding and treating various cardiovascular conditions.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: James, Joel — Indiana University Indianapolis
- Study coordinator: James, Joel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.