Investigating how amino acid metabolism affects glioblastoma growth
Official title: Targeting Amino Acid Metabolism in Glioblastoma
Funded at University of Pittsburgh at Pittsburgh · NIH-10980641 · Data updated 2026-11-12
This study is looking at how glioblastoma, a tough type of brain cancer, uses certain building blocks called amino acids to grow and avoid the immune system, with the hope of finding new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $574,427 |
| NIH project number | 1R01NS134724-01A1 |
| Project ID | NIH-10980641 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking new treatment options.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research focuses on glioblastoma, one of the most aggressive brain cancers, and aims to understand how specific amino acids are utilized by tumor cells. By examining the metabolism of these amino acids, the study seeks to uncover how they contribute to tumor growth and immune evasion. The approach involves comparing the metabolic pathways of glioblastoma cells with those of normal neural stem cells to identify unique vulnerabilities in the tumor cells. This could lead to new therapeutic strategies targeting these metabolic processes.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve survival rates and quality of life for glioblastoma patients.
How similar studies have gone: Previous research has shown promise in targeting metabolic pathways in cancer treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Rich, Jeremy N — University of Pittsburgh at Pittsburgh
- Study coordinator: Rich, Jeremy N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.