Investigating how Alzheimer's genetic risk affects dementia in Parkinson's disease
Official title: The Role of Alzheimer's Disease Genetic Risk in Predicting Parkinson's Disease Dementia
Funded at University of Pennsylvania · NIH-10892147 · Data updated 2026-11-12
This study is looking at how certain genes linked to Alzheimer's might affect memory and thinking in people with Parkinson's disease, and it hopes to find new ways to help those experiencing dementia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $209,063 |
| NIH project number | 5K23NS114167-05 |
| Project ID | NIH-10892147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease, particularly those who may be at risk for developing dementia.
✕Less likely to help
Patients without a diagnosis of Parkinson's disease or those who do not have genetic risk factors for Alzheimer's may not benefit from this research.
What this research studies
This research explores the connection between genetic risk factors for Alzheimer's disease and the development of dementia in individuals with Parkinson's disease. It aims to understand how these genetic factors may predict cognitive decline and the presence of specific biomarkers associated with Alzheimer's pathology. By analyzing data from various research cohorts, the study seeks to identify patterns that could lead to new treatment strategies for dementia in Parkinson's patients. Participants may contribute to a better understanding of the neurobiology underlying these conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and potentially treating dementia in patients with Parkinson's disease.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between Alzheimer's pathology and cognitive decline in Parkinson's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Tropea, Thomas Francis — University of Pennsylvania
- Study coordinator: Tropea, Thomas Francis
Related research
Other NIH-funded projects on the same topics.
-
Global picture of dementia risk and memory loss across the world
A large international effort gathers data from many studies to understand how dementia and memory problems develop around the world, using shared information to reveal patterns and risk factors.
-
Automated language analysis for Alzheimer’s disease and frontotemporal dementia in Latino and English speakers
A low-cost, automated speech and language analysis tool is being developed to help identify Alzheimer’s disease or frontotemporal dementia in Latino and English-speaking people.
-
Automated language analysis for Alzheimer’s and frontotemporal dementia across Latino and English-speaking groups
A low-cost, automated language study aims to help diagnose and understand Alzheimer’s and FTD in diverse Spanish- and English-speaking communities.
-
Automated language analysis to help diagnose Alzheimer’s and frontotemporal dementia in Latino and English speakers
A low-cost, computer-based method analyzes speech and language to help identify Alzheimer’s disease or frontotemporal dementia in Latino and English-speaking people.
-
Automated language analysis for Alzheimer's and frontotemporal dementia in Latino and English-speaking communities
A low-cost, computer-based language analysis method is being developed to help identify Alzheimer’s disease and frontotemporal dementia in Latino and English-speaking people.
-
Automated language analysis to detect Alzheimer’s and frontotemporal dementia in Latino and English-speaking adults
A low-cost, computer-based language and speech analysis tool will help identify Alzheimer’s disease and frontotemporal dementia in Latino and English-speaking adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.