Investigating how Alzheimer's disease and trauma affect cognitive decline in older veterans
Official title: Early Cognitive Impairment as a function of Alzheimer's Disease and Trauma
Funded at VA Boston Health Care System · NIH-11098494 · Data updated 2026-11-12
This study is looking at how experiences like combat and injuries might affect the memory and thinking skills of veterans over 65 who have Alzheimer's, and it aims to find out how these factors work together with genetics to influence their brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Boston Health Care System NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005749-03 |
| Project ID | NIH-11098494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans aged 65 and older who may have experienced trauma or have a family history of Alzheimer's disease.
✕Less likely to help
Patients who are younger than 65 or do not have a history of trauma or Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the relationship between Alzheimer's disease, trauma, and cognitive impairment in veterans aged 65 and older. It examines how factors such as combat exposure, PTSD, and traumatic brain injuries may interact with genetic predispositions to increase the risk of dementia. By utilizing data from one of the largest biobanks linked to electronic medical records, the study aims to identify specific genetic and environmental interactions that contribute to cognitive decline. Participants may undergo assessments to evaluate their cognitive health and provide valuable data for understanding these complex relationships.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or managing cognitive decline in older veterans.
How similar studies have gone: Previous studies have shown promising results in understanding the interactions between genetic factors and environmental exposures in cognitive decline, indicating that this approach has potential for success.
Where this research is happening
-
VA Boston Health Care System
Boston, United States Active
Researchers
- Principal investigator: Logue, Mark W — VA Boston Health Care System
- Study coordinator: Logue, Mark W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.