Investigating how alternative splicing affects glioblastoma
Official title: Using proteogenomics to assess the functional impact of alternative splicing events in glioblastoma
Funded at Swedish Medical Center, First Hill · NIH-10756532 · Data updated 2026-11-12
This study is looking at how changes in gene splicing might help glioblastoma, a tough brain tumor, grow and spread, with the hope that what we learn could lead to better ways to diagnose and treat this cancer for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Swedish Medical Center, First Hill NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $218,604 |
| NIH project number | 5R21CA267394-02 |
| Project ID | NIH-10756532 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glioblastoma who are seeking innovative treatment options.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research focuses on glioblastoma, the most aggressive type of brain tumor, which has a very low survival rate. The study aims to explore how alternative splicing of genes contributes to the development and progression of this cancer. By using advanced techniques in proteogenomics, researchers will identify and validate specific splicing events that may lead to the production of unique proteins associated with tumor growth and invasion. Patients may benefit from insights that could lead to new diagnostic markers and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and targeted therapies for glioblastoma patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of alternative splicing in various cancers, suggesting that this approach could yield valuable insights for glioblastoma as well.
Where this research is happening
-
Swedish Medical Center, First Hill
Seattle, United States Active
Researchers
- Principal investigator: Cobbs, Charles S — Swedish Medical Center, First Hill
- Study coordinator: Cobbs, Charles S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.