Investigating how alternative splicing affects breast cancer genetics
Official title: Alternative splicing and isoform expression as mediators for the genetic etiology of breast cancer
Funded at University of Tx Md Anderson Can Ctr · NIH-10950516 · Data updated 2026-11-12
This study is looking at how different versions of genes might affect breast cancer, using advanced techniques to find new information that could help create more personalized treatments for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 5, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $407,321 |
| NIH project number | 1R21CA293419-01 |
| Project ID | NIH-10950516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of breast cancer or those diagnosed with breast cancer who are interested in genetic factors influencing their condition.
✕Less likely to help
Patients without a genetic predisposition to breast cancer or those who do not have breast cancer may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the role of alternative splicing and isoform expression in breast cancer by analyzing genetic data. It aims to enhance existing genome-wide association studies (GWAS) by integrating them with functional genomics datasets, which will help identify specific genetic mechanisms linked to breast cancer risk. By utilizing advanced RNA sequencing techniques, the study will re-evaluate existing data to uncover previously unrecognized isoforms that may contribute to breast cancer development. Patients may benefit from insights that could lead to more personalized treatment options based on their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of breast cancer genetics, potentially resulting in more targeted and effective treatments for patients.
How similar studies have gone: Previous research has shown promise in using similar approaches to uncover genetic mechanisms in other cancers, indicating potential for success in this area as well.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Bhattacharya, Arjun — University of Tx Md Anderson Can Ctr
- Study coordinator: Bhattacharya, Arjun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.